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59 Although some effects of GLP-1 RAs, particularly weight loss, are linked to direct effects of GLP-1 RAs in brain areas responsible for appetite, satiety, food behaviour and other central regulatory mechanisms, data regarding the potential impact of therapy on mental health among HF patients are lacking

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The most recent advance in this area is known as nasoalveolar molding (NAM)

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8 Direct action on the skin is a possible mechanism, as GLP-1Rs have been shown to be expressed in the skin of newborn mice and cultured skin cells

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Saudi J Biol Sci 24:14101417

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