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Despite its benefits, the clinical application of orlistat is often hindered by its gastrointestinal side effects and modest weight loss results, prompting the search for alternative and adjunct therapies, including natural products and novel PL inhibitory peptides that may offer better tolerability and effectiveness in managing obesity [7,8,9]

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Heres what the clinical evidence actually shows: Short-term (12 weeks): Average weight loss of 3-5% of total body weight above placebo

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Another major pharmaceutical player, Eli Lilly, is preparing its own oral weight loss treatment expected later this year

A possible explanation could be related to the different effects of insulin on the thyroid gland