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Most peptide regimens used in obesity and metabolic research show good overall tolerability, but they still carry risks, particularly for patients with diabetes, cardiovascular disease, or cancer history

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Patients who previously consumed high-fat diets may need to make substantial adjustments, but these modifications typically become easier as new eating patterns are established and weight loss progresses

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doi: 10.1016/j.cmet.2012.11.012

Afferent fibers from the trigeminal ganglion synapse on neurons in the trigeminal cervical complex (2), and ascending pathways transmit signals to various brain regions, causing pain, cutaneous allodynia, and sensory disturbances like photophobia and phonophobia (6, 34)