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There were no adverse maternal or offspring effects in rats treated throughout organogenesis and lactation with 1.5 mg/kg/day phentermine and 10 mg/kg/day topiramate (approximately 2- and 3-times clinical exposures at the MRHD, respectively, based on AUC)

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Table 1 summarizes the demographic and clinical characteristics of these patients during the acute phase and at the 12-month follow-up