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Understanding Dual Agonism: The Tirzepatide Mechanism GIP and GLP-1 Receptor Biology Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 represent two key incretin hormones that regulate postprandial glucose homeostasis

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PMID 24725840

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By hitting four different hormone receptors at the same time, we hope to improve the chances of averaging out such variation toward the goal of achieving greater and more consistent overall effectiveness. A second issue is that patients tend to regain weight after discontinuing currently available GLP-1 related drugs, said Beinborn, who notes that lifestyle changes should ideally be a complement to medication treatment