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Science 381, 502508
What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
Below, across-subjects results are reported as (mean (median) SD)
Here, we showed the expression of metabolizing enzymes, which were predominated in the OB of EE mice
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