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If nausea or vomiting persists despite these measures, and after considering dose reduction, the use of antiemetic and/or prokinetic medications may be appropriate [15]

In adults with type 2 diabetes and obesity, the top dose cut weight up to an average of 20.8% at 80 weeks, with A1C down up to an average of 1.6% (efficacy estimand)

Real-world clinical experience shows many patients achieving excellent weight loss results on the combination

TMAO accelerates atherosclerosis through multiple mechanisms

However, their clinical translation has been hindered by poor water solubility, rapid metabolism, low bioavailability, and fast excretion

Inhibition of glucose utilization by fatty acids is a type of glucose intolerance that may lead to insulin resistance