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HIV Clin

Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms

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The average plasma GSH/GSSG ratio is reported to be in the range 2528 M with a large standard deviation [14, 15], and in the model it is 26.5

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The consequent block of autophagy triggers the further accumulation of cellular waste like damaged mitochondria and protein aggregates, which contributes to overall cellular damage and leads to neuronal cell death and neurodegeneration 53