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These factors indicate that the GLP-1 RA group is more severely affected by diabetes compared to the DPP-4i group, and the GLP-1 RA group may thus be subject to residual confounding associated with higher fracture risk

Patients with T1D or T2D and CKD with venous thromboembolism should preferably be treated with direct oral anticoagulants over vitamin K antagonists in patients with CKD stages 14 (dabigatran up to stage 3b) (2C)

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Still, studies are not unanimous