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95% CI -60.7, -5.6

At least this is what we have seen both in a trial we've conducted ourselves years back with MAR709, our dual-agonist, but also so far in the trial in Phase II and the escalation trials that our colleagues at Eli Lilly have done

Furthermore, gene expression analysis of intestinal epithelial cells (IECs) showed no significant differences in mRNA levels of Gip and Glp1 and the potential upstream transcription factor regulatory factor X6 ( Rfx6 ) in duodenum, jejunum, ileum, and colon, while expression of pancreatic and duodenal homeobox 1 ( Pdx1 ) was higher in jejunum of PAR2-R38E mice when compared with PAR2-G37I and WT mice (Supplemental Figure 2C)