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Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites

Drug development continues to face marked inefficiencies, with approximately 90% of drug candidates failing to reach approval despite extensive preclinical testing ( in vitro models, although cost-effective and suitable for high-throughput studies, lack the architectural complexity and biochemical microenvironment of human tissues

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Plasma was collected in EDTA-tubes from each patient before the surgical procedure