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Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

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The net structural picture is a peptide of roughly 83 amino acids (the 70-residue IGF-1 core, modified at position 3, plus the 13-residue N-terminal extension), with a molecular weight of approximately 9.19.2 kDa noticeably larger than native IGF-1s ~7.6 kDa