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We next considered the potential role of neoantigens resulting from SNVs in early disease by predicting neoantigens for patient-specific HLA-A, -B and -C alleles using NetMHC4.0 31,32 (see Supplementary Methods) and examining the loss of these predicted neoantigens due to LOH in late disease

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Give it time before judging whether it's working

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Baseline characteristics were compared by the pharmacotherapy, i.e., GLP-1 analog therapy alone or combined with bupropion/naltrexone

That is a reason for proper medical supervision not for dismissal or for DIY supplementation