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These medications should also be avoided in patients with a history of acute or chronic pancreatitis, which is a painful and potentially fatal inflammation of the pancreas

In AD mouse models, pathophysiological changes, such as anti-apoptotic effects, reduced A deposition and phosphorylated hippocampal tau, protection from synapse loss, reduced inflammatory and oxidative stress response in the cortex and hippocampus, and increased BDNF have been observed [119,120,121]

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Alprostadil was administered intravenously twice daily for 6 days