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Ignoring metabolic markers Weight is one data point

Power calculations suggest that previous studies would have had limited power to detect an effect size similar to that identified in our study (Supplementary Table 23), and also differed in terms of drug type, disease cohort and analytical choices

Not even close

You can read the full article at LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept: Cell Metabolism

14 The adoption of Tyr 1 by tirzepatide may impair its GLP-1 activity while supporting its GIP activity

Broader tissue distribution