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A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care
People exposed to nitrous oxide (medical or recreational use) may develop functional B12 deficiency, as the gas inactivates B12-dependent enzymes, potentially requiring supplementation
Furthermore, the effect of BPC 157 is due to its interaction with and modulation of the NO system, and its interaction with prostaglandin, dopamine, and serotonin systems has also been documented
( Journal of Orthopaedic Research , 2010) showed that BPC-157 enhanced medial collateral ligament (MCL) healing in rats, with results across multiple routes of administrationintraperitoneal, local application, and even oral
