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An imbalance between food intake, metabolism and energy expenditure is the principal mechanism responsible for excess weight gain and arises from a complex interplay between genetic and epigenetic factors and an obesogenic environment [3,5]

Through these various mechanisms, GLP-1 regulates blood sugar and extends the feeling of fullness following a meal

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2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

That is where the conversation becomes more nuanced