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Larger, medication-controlled studies are needed to clarify whether synaptic loss is a core feature of LLD, is associated with A and Tau and whether synaptic loss marks a subgroup at risk for persistent symptoms and cognitive decline, as is the focus of an ongoing study [249]

Among patients tracking their symptoms, the top complaints were fatigue, post-exertional malaise, and brain fog

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In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role

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