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As Young remembers, 'We couldnt predict weight loss or weight gain with these drugs.' One of the challenges was that enhanced insulin secretion normally increases body weight

We previously showed that while dietary free DHA did not appreciably increase brain DHA, LPC-DHA (both sn-1 acyl and sn-2 acyl isomers) markedly increased brain DHA, as well as BDNF, and improved brain function in normal male mice 24

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To appreciate this fact one can look to research done on calorie-restriction diets