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Structural studies have shown that GLP-1R activation involves a complex network of interactions spanning the ECD and the transmembrane (TM) core, including deep penetration of the GLP-1 N-terminus into the orthosteric cavity and stabilization of characteristic active-state rearrangements within the TM bundle (Cong et al., 2022

Given our findings, future research with Dandelion data will focus on (i) investigating the heterogeneity in treatment response to GLP-1s, (ii) modeling predictors of patient responsiveness, and (iii) analyzing unstructured clinical data to understand the impact of GLP-1s on measures beyond weight loss and HbA1c (e.g., loss or preservation of lean body mass)

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Our role, as we see it, is to support this dual-pronged advancement

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