The convergence of shortened telomeres and unrepaired DNA lesions triggers the senescence-associated secretory phenotype (SASP), through which granulosa cells secrete inflammatory cytokines (IL6, IL8, TNF-), matrix metalloproteinases (MMP1, MMP3), and growth factors (VEGF, FGF2) [185, 200,201,202,203,204]
Comparing the expression pattern of NAPRT and NAMPT gene in human tumor cell lines versus normal tissues, the researchers found a great variability in mRNA and protein levels of NAPRT in tumor cells
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