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Study finds Botox wears off quicker in GLP-1 patients In October 2025, a paper entitled Computational modelling the impact of GLP-1 receptor agonists on botulinum toxin A: Evidence for reduced treatment durability across neurologic and aesthetic indications , was published online

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These results are consistent with those of GLP-1R and SSTR subtype 2 (SSTR2) mRNA expressions, in which insulin-positive tumors showed significantly high GLP-1R and relatively low SSTR2 mRNA expression levels (Fig

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