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Metabolic Pharmaceuticals ultimately did not pursue Phase 3 trials for obesity, and the company's pipeline shifted toward other indications

Sonthalia, S., et al

Clinical and animal studies have demonstrated that microbiota reconstruction through probiotics, prebiotics, exclusion diets, or fecal microbiota transplantation can effectively alleviate inflammation

The binding of the SARS-CoV-2 spike glycoprotein with ACE2, which triggers the virus-mediated cellular uptake, can also cause a burst of inflammatory cytokine release (a cytokine storm) partially because of the decreased availability of functional ACE2

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Finally, the protonated glutamate residue donates a hydrogen to the amine of the -linked peptide, releasing an amino acid with a free amino group (Figure 3) (Oakley et al., 2008)