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In vitro studies using HGL5 cells showed that melatonin reduced oxidative stress markers, improved mitochondrial function, and restored expression of metabolic genes

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1: Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ

Mitochondria: Cellular organelles that generate ATP energy

This is a small absolute amount for an initially understaffed group who cope with an expanding elderly population as well as the consequences of changes in hospital practice