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Clinical trials reported an average weight reduction of 20.9% among participants on the highest dose

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Among the main antioxidant enzymes involved in ROS removal belong superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and peroxiredoxins (Halliwell 2024)

This profile distinguishes tirzepatyd from compounds acting exclusively through a single incretin receptor and underpins its importance in studies of metabolism and hormone signalling

No human trial established reversal of frailty, disease risk, organ ageing or mortality