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5 About the SELECT Trial SELECT (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity) was a multicenter, randomized, double-blind, placebo-controlled, event-driven superiority trial designed to evaluate the efficacy of Wegovy 2.4 mg versus placebo as an adjunct to cardiovascular standard of care for reducing the risk of major adverse cardiovascular events in people with established CVD with overweight or obesity with no prior history of diabetes

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Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients

As GLP-1-based therapies reshape diabetes and obesity care, ongoing post-marketing safety monitoring will be essential to ensure that benefits continue to outweigh risks across diverse patient groups. She added future research may continue evaluating long-term and rare [GI] outcomes, particularly as these agents are increasingly prescribed for weight management in individuals without diabetes. For more information: Wajd Alkabbani, PhD, can be reached at [email protected].