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Still, another study found that semaglutide exposure was reduced by approximately 40% when administered with 240 versus 50 mL water [22], suggesting that greater than 120 mL water with dosing may negatively influence the absorption of oral semaglutide

Chappell DL, Lee AY, Castro-Perez J, Zhou H, Roddy TP, Lassman ME, Shankar SS, Yates NA, Wang W, Laterza OF

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