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Gradually increasing the dosage is intended to minimize side effects and help the body adjust to the medication's effects, including constipation

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In addition, hepatocytes have the ability to induce innate and adaptive immune defenses to dampen the inflammatory response during necrosis

In certain cases, underlying health conditions might also affect how the body metabolizes the drug, prompting either an increase or decrease in dose

Sex, body weight, baseline neuroendocrine status, concurrent compounds, and study objectives all influence appropriate dosing in research protocols