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The Pickart 2018 review documented effects on collagen synthesis, anti-inflammatory signaling, nerve regeneration, and stem cell recruitment (Pickart et al., Int J Mol Sci, 2018)

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B12 supplementation is appropriate for individuals with confirmed deficiency, vegans, older adults, those with malabsorption disorders, people who have had bariatric surgery, and those on long-term medications such as metformin or proton pump inhibitors