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This multidimensional, target-specific strategy holds promise for enhancing therapeutic efficacy while minimizing systemic side effects.Future large-scale longitudinal randomized controlled trials should prioritize structural and functional endpointssuch as TEWL, AMP expression, and tissue remodeling markerswhile incorporating refined stratification variables, including VDR polymorphisms, metabolic-nutritional status, and biological aging indices, to identify responsive subpopulations, optimize dosage windows, and enhance intervention efficacy

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Clinical impact: Weight loss plus improvements in cholesterol, blood pressure, and triglycerides

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Balanced Diet : Maintain a well-rounded diet to support overall health and ensure you are getting other essential nutrients

Take With Meals Take with food, ideally a higher-fat meal for better absorption