Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes
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These metabolites spanned across five key classes: Carbohydrate Metabolomics, Nucleotide and Its Metabolites, Organic Acids and Derivatives, Phosphate Sugars, and Phosphoric Acids, suggesting a metabolic realignment in response to the redox disequilibrium induced by the absence of GR
Further studies have found that when intracellular iron and lipid disorders are disturbed, 15-hydroperoxy-arachidonoyl-phosphatidyl-ethyl amino alcohol (15-HpETE-PE) will accumulate, resulting in the appearance of ferroptosis [4, 34, 50], and one of the catalysts of this reaction may be the ALOX15 and scaffold protein PE-binding protein-1 (PEBP1) complex [51, 52], NO can inhibit the catalysis of this complex, thereby inhibiting ferroptosis
