Collective findings from these studies underscore persistent translational challenges, including size heterogeneity, rapid renal clearance, and limited long-term toxicological data, highlighting the need for improved targeting, surface modification, and synthesis control to support clinical translation [190]
Cagrilintide was well-tolerated with no new safety findings and no increase in the number of TEAEs with increasing renal or hepatic impairment
Nature (2022) 604(7907):697+
References GLP-1 Agonists: Diving into the Data Marx N, Federici M, Schtt K, et al
It consists of two alpha (135 kDa) subunits, which bind IGF-1, and two beta (90 kDa) subunits
DUALMINIPROTEIN TECHNOLOGY