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In the pivotal SURPASS trials evaluating tirzepatide for type 2 diabetes, nausea occurred in 1222% of patients depending on the dose (5 mg, 10 mg, or 15 mg weekly), compared to approximately 58% with placebo
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The safety data for semaglutide microdosing is also limited because microdosing protocols are not supported by large-scale clinical trials or rigorous testing
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