Meta-analyses covering thousands of patients show significant reductions in both the duration and severity of diarrhea across multiple causes: antibiotic-associated, infectious, and medication-induced
And it doesnt cause weight gain, is highly effective when taken consistently, doesnt cause hypoglycemia, and its relatively affordable. While the impact of metformin is significantly more subtle and gradual than that of GLP-1s, its still beneficial for almost anyone with diabetes, regardless of other medications
Meta-analyses of oral berberine trials have indicated improvements in fasting blood glucose and HbA1c levels, though study quality varied considerably
Davignon J, Ganz P: Role of endothelial dysfunction in Atherosclerosis
Titration pacing matters In the Phase 2 NEJM trial, GI side effect rates nearly doubled when participants jumped to 8 mg instead of climbing gradually from 1-2 mg
It's an older GLP-1 option and may be suitable for some people