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First, it might not work anymore

Given that dopamine is secreted by the gut and regulates insulin secretion in the pancreas, we aimed to determine its regulation by nutritional cues and its role in regulating glucagon-like peptide 1 (GLP-1) action in WAT

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If a patient reaches 2.4 mg and is still not achieving clinically meaningful weight loss (defined as at least 5 percent of body weight), the medication may not be the right fit

Prog Neurobiol 92(3):442462 Vrang N, Phifer CB, Corkern MM, Berthoud H-R (2003) Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons

By targeting both GLP-1 and GIP receptors, tirzepatide has a stronger effect on blood sugar control and weight loss than older medications that only work on GLP-1