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Inhibition of Notch signaling by a gamma-secretase inhibitor attenuates hepatic fibrosis in rats

In a recent head-to-head study , people taking tirzepatide lost an average of 20.2% of their body weight after 15 months of treatment, while those taking semaglutide lost 13.7%

As a result, there is inhibition of intracellular cholesterol synthesis mainly in the liver

If levels remain suppressed, extended PCT or a different approach may be necessary