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That is a difference of approximately 10 pounds in the metric often used for regulatory assessment

10.1038/nrc3419 13 AokiH.TakadaY.KondoS.SawayaR.AggarwalB

(33068459) Propofol infusion syndrome, with findings including: Clinical features: Bradycardia, hypotension

Acknowledgements The authors wish to acknowledge Humphrey Chukwudi Omeoga, of Thomas BegLey Laboratory, Department of Biological Sciences, State University of New York, at Albany, New York USA for using his licensed accessed BioRender for the diagrams sketching

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Unfortunately, while antidiabetics and antihyperlipidemic help in CKD management, they are excreted by the kidneys and have a high risk of drug accumulation in renal cells which significantly contributes to CKD [221]