Pooled estimates derived from the included reviews are shown in Supplementary Figures S8, S9
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Pharmacokinetic assessment is crucial to understand how GLP-1 receptor agonists are absorbed, distributed, metabolized, and excreted, guiding optimal dosing, and ensuring therapeutic efficacy
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Glucagon turns off glycolysis in the liver, causing glycolytic intermediates to be shuttled to gluconeogenesis
The study suggests that simultaneous stimulation of GIP and GLP-1 receptors may offer a promising new treatment approach for type 2 diabetes