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In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within Keap1 allows Nrf2 to escape ubiquitination, accumulate within the cell, and translocate to the nucleus, where it can promote its antioxidant transcription program

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RNA extraction A total of 200 l of EDTA plasma was extracted using the automated platform Nuclisens easyMAG (bioMrieux, Boxtel, Netherlands) according to the manufacturer's instructions

This creates a supportive cycle that keeps the liver's defense system strong