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In: Caballero B, Allen L, Prentice A, editors

The relationship remained consistent after adjustment for study duration, baseline body mass index, sex distribution and diabetes status, at 0.36 millimetres of mercury per one per cent weight loss

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An initial loss of first phase insulin response contributes to elevated postprandial plasma glucose concentrations.[3] The pathological loss of -cell function may be the result of a number of factors including -cell secretory defects, glucotoxicity due to hyperglycemia, lipotoxicity due to dislipidemia, and possibly abnormalities in secretion of, or response to, incretin hormones

The Journal of Prevention of Alzheimers Disease 2020;7, 146-151