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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Nature Medicine 2019;25:1096-1103 Yoon HS, Cho CH, Yun MS, et al

Trial data show an average increase of about 2.7 to 3.2 beats per minute in some studies, and real-world program data report a slightly higher proportion of people reporting increased heart rate on semaglutide versus not on it (for example, roughly 16 percent versus 11 percent after two years in an extensive registry analysis)

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