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A limited number of studies have reported increased systemic levels of claudins as a marker for impaired intestinal barrier function, e.g., increased serum claudin-5 in children with attention deficit hyperactivity disorder (67) and increased urinary claudin-3 in patients with active Crohn's disease which was associated with decreased claudin-3 staining in intestinal biopsies (68)

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Free radicals increase because of various toxins, industrial chemicals, air pollutants, UV light, certain drugs, and pesticides.[xi] Free radicals in excess pair with other free electrons in cells resulting in decreased cellular function and disease

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