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The role of CYP3A4 in APAP metabolism is controversial, with findings ranging from no significant contribution to it playing the primary role in APAP oxidation [33,3537]

A binary mobile phase system was used, buffer A: 0.1% (v/v) formic acid (FA) in water and buffer B: 0.1% (v/v) FA in acetonitrile (ACN)

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