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Oral semaglutide 2550 mg produces the largest average reduction, followed by orforglipron closely behind ( Nausea and vomiting increase with higher semaglutide exposure, with the 50 mg oral dose showing the greatest frequency, especially during dose escalation

Because it enhances detox enzyme activity, it may either reduce medication effectiveness or change how quickly drugs are cleared from the body

BMC Genomics 18, 282

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Some people need medical detox first