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P.SaponeA.CarielloR.et al (2013)

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Consult with a qualified healthcare provider before beginning any supplementation protocol.

Randomized trial of a high protein, partial meal replacement program with or without alternate day fasting: similar effects on weight loss, retention status, nutritional, metabolic, and behavioral outcomes

Possible production of free radicals through an erythrocyte-mediated positive feedback mechanism

Another challenge is that in many countries, Spirulina is marketed as a dietary supplement, which may not require rigorous pre-market evaluation