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This reminds me Toni Vidal-Puig MD PhD FRCP FMedSci MAE MBA comment about organ vulnerability: obesity may be heterogeneous in terms of which organ becomes the first weak link in the chain of events that form vicious cycles

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Further, Jang et al

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As a result, it reduces tissue inflammation ( 2.1.2 Phenylpropanoids Phenylpropanoids are composed of a benzene ring and a propyl chain and include mainly coniferin and phenylethanol glycosides, which are abundant in Scrophulariae Radix and possess diverse biological activities, such as antioxidation, antitumor, and immunomodulation ( Coniferin helps scavenge free radicals, while phenylpropanoids increase the activity of antioxidant enzymes, protecting cells from oxidative damage ( 2.1.3 Organic acids Hippuric and caffeic acids are key organic acids in Scrophulariae Radix ( 2.1.4 Volatile oils The volatile oils of Scrophulariae Radix , such as caryophyllene and eugenol, have strong antibacterial and analgesic effects (37), which reduce thyroid-related symptoms in patients