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The current GHK-Cu FDA approval status is mainly influenced by high drug development costs, limited clinical data, formulation stability challenges, and its established role as a GHK-Cu cosmetic ingredient

Consequently, it seems that the most lucrative application of antimicrobial peptides and proteins is a local treatment rather than a systemic application

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Mild acidic pH ~5.0 matches the skin's natural acid mantle so it doesn't disrupt the barrier