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The procedures were approved by the Ethics Committee of the Chinese Academy of Medical Sciences, Beijing, China and conformed to international animal care guidelines
The -cell function is restored in T2DM rats
In vitro studies have shown that addition of DPP-4 is associated with impaired insulin signaling in primary human adipocytes, skeletal muscle, and smooth muscle cells (79), while conversely, silencing Dpp4 (using short interfering RNA) resulted in improved adipocyte insulin responsiveness (89)
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
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