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and Jacob Whitsitt, MD KSDDS Newsletter Educational Coordinator - Demi Elrod (UMKC - SOM) Abbreviations used: HHV-8: human herpesvirus 8 JAK: Janus kinase KS: Kaposi sarcoma MSM: men-who-have-sex-with-men UC: ulcerative colitis Introduction Kaposi sarcoma (KS) is a rare neoplasm of lymphatic endothelium-derived cells infected with human herpesvirus 8 (HHV-8).1 There are 4 variant forms of KS: classic, AIDS-related, endemic (African), and iatrogenic.1 Recent literature has noted an emerging fifth variant of KS seen in men-whohave-sex-with-men (MSM) but who are HIV-seronegative.2 With the growing use of immune modulating medications such as Janus kinase (JAK) inhibitors for a range of inflammatory diseases, there have been an increasing number of reported iatrogenic KS cases associated with these medications.3 We report a case of KS in a patient who is MSM with a history of severe ulcerative colitis (UC) treated with upadacitinib, highlighting both the potential risk of malignancy associated with JAK inhibitors and risk of KS in MSM patients without HIV

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