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But tirzepatide has already proven itself across multiple large-scale trials involving tens of thousands of participants, with established dosing protocols, known side effect patterns, and widespread clinical use

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Which HRT delivery methods are affected Affected by GLP-1 medications (oral delivery): Oral estrogen tablets (conjugated equine estrogens, estradiol) Oral progesterone (micronized progesterone, such as Utrogestan) Oral progestins (norethisterone, medroxyprogesterone) Oral testosterone (testosterone undecanoate) NOT affected by GLP-1 medications (non-oral delivery): Transdermal estrogen patches Topical estrogen gels and creams Vaginal estrogen rings or suppositories Progesterone-releasing IUD (Mirena) Transvaginal progesterone Testosterone injections Testosterone pellets Testosterone patches or gels The distinction is simple